The Global Market for Nanocoatings in the Medical Industry

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Published March 9 2021, 233 pages, 50 tables, 64 figures

In medical and healthcare facilities it is necessary to equip materials and surfaces with a high level of hygiene using antimicrobial agents to protect them against bacteria and other micro organisms to prevent infections caused by bacteria and contribute significantly to reduce health costs. Challenges in medical device coatings include:

  • biocompatibility;
  • coating adhesion;
  • uniform coverage over challenging shapes;
  • strength;
  • durability.

 

Benefits of nanoscale coatings in this sector include long lasting antimicrobial effect, constant release of the active substance, effectiveness against bacteria and other micro-organisms, no chemical impurities, easy processing, no changes to the characteristics of the equipped material, and no later discolouration of the equipped material. Nanocoatings are already finding application in life sciences & healthcare in enabling anti-bacterial surfaces for medical catheters, added to paints and lacquers used to coat operating tables, door knobs and door handles in hospitals and as ultra-hard porous coatings for surgical and orthopedic implants like screws, plates or joint implants.

The medical market will be a high growth area for nanoscale coatings over the next 5-10 years, and this is reflected in the high number of companies exploiting technology in this area, especially in the anti-microbial domain. The main market driver in this area is the prevention of the spread of deadly infections in medical facilities. Drug-resistant bacteria, the so-called "superbugs," are a growing problem in hospitals worldwide and poor hygiene among staff is often blamed for the spread of such infections.

Report contents include: 

  • Advantages of nanocoatings in the medical and healthcare industry.
  • Types of nanocoatings.
  • Anti-viral and anti-microbial nanocoatings industry analysis.
  • Types of nanomaterials utilized in medical nanocoatings. 
  • Profiles of 107 companies. 

 

Table of contents (.pdf)

 

1              EXECUTIVE SUMMARY   18

  • 1.1          Why nanocoatings?        18
  • 1.2          Advantages over traditional coatings       18
  • 1.3          Improvements and disruption in coatings markets            20
  • 1.4          Anti-viral nanoparticles and nanocoatings             22
    • 1.4.1.1   Reusable Personal Protective Equipment (PPE)   24
    • 1.4.1.2   Wipe on coatings             24
    • 1.4.1.3   Facemask coatings           24
    • 1.4.1.4   Long-term mitigation of surface contamination with nanocoatings             25
  • 1.5          End user market for nanocoatings            26
  • 1.6          The nanocoatings market in 2020              29
  • 1.7          Global market size, historical and estimated to 2020         29
    • 1.7.1      Global revenues for nanocoatings 2010-2030       29
    • 1.7.2      Regional demand for nanocoatings          30
  • 1.8          Market challenges           31
  • 1.9          Toxicity and environmental considerations           32
  • 1.10        Impact of COVID-19 on the market           33
  • 1.11        Market outlook in 2021  33

 

2              NANOCOATINGS TECHNICAL ANALYSIS  35

  • 2.1          Properties of nanocoatings          35
  • 2.2          Benefits of using nanocoatings   36
    • 2.2.1      Types of nanocoatings   37
  • 2.3          Production and synthesis methods          37

 

3              NANOMATERIALS IN MEDICAL NANOCOATINGS 50

  • 3.1          Metallic-based coatings 50
  • 3.2          Polymer-based coatings 51
  • 3.3          Graphene           53
    • 3.3.1      Properties           53
    • 3.3.2      Graphene oxide 55
      • 3.3.2.1   Anti-bacterial activity      55
      • 3.3.2.2   Anti-viral activity              56
    • 3.3.3      Reduced graphene oxide (rGO) 56
    • 3.3.4      Application in medical and healthcare     57
      • 3.3.4.1   Anti-microbial wound dressings 57
      • 3.3.4.2   Medical textiles 58
      • 3.3.4.3   Anti-microbial medical devices and implants        58
  • 3.4          Silicon dioxide/silica nanoparticles (Nano-SiO2)  59
    • 3.4.1      Properties           59
    • 3.4.2      Application in medical and healthcare     60
      • 3.4.2.1   Antimicrobial and antiviral activity            60
      • 3.4.2.2   Easy-clean and dirt repellent coatings     60
  • 3.5          Silver nanoparticles (Ag-NPs)      61
    • 3.5.1      Properties           61
    • 3.5.2      Application in medical nanocoatings        61
      • 3.5.2.1   Textiles 63
      • 3.5.2.2   Wound dressings             63
      • 3.5.2.3   Air filtration        63
    • 3.5.3      Companies         63
  • 3.6          Titanium Dioxide nanoparticles (TiO2-NPs)           65
    • 3.6.1      Properties           65
      • 3.6.1.1   Exterior and construction glass coatings 67
      • 3.6.1.2   Outdoor air pollution      68
      • 3.6.1.3   Interior coatings               69
      • 3.6.1.4   Improving indoor air quality        69
      • 3.6.1.5   Medical facilities               70
    • 3.6.2      Application in medical nanocoatings        70
      • 3.6.2.1   Antimicrobial coating indoor light activation         70
  • 3.7          Nano-Zinc oxide (nano-ZnO/ ZnO-NPs)   71
    • 3.7.1      Properties           71
    • 3.7.2      Application in medical nanocoatings        72
      • 3.7.2.1   Sterilization dressings    72
      • 3.7.2.2   Anti-bacterial surfaces in construction and building ceramics and glass     73
      • 3.7.2.3   Antimicrobial packaging 73
      • 3.7.2.4   Anti-bacterial textiles     73
  • 3.8          Nanocellulose   75
    • 3.8.1      Properties           75
    • 3.8.2      Application in medical nanocoatings        76
      • 3.8.2.1   Cellulose nanofibers       76
      • 3.8.2.2   Cellulose nanocrystals (CNC)       76
  • 3.9          Carbon nanotubes           76
    • 3.9.1      Properties           76
    • 3.9.2      Application in medical nanocoatings        76
  • 3.10        Fullerenes           77
    • 3.10.1    Properties           77
    • 3.10.2    Application in medical nanocoatings        78
  • 3.11        Copper nanoparticles (Cu-NPs)  78
    • 3.11.1    Properties           78
    • 3.11.2    Application in medical nanocoatings        79
    • 3.11.3    Companies         79
  • 3.12        Gold nanoparticles (Au-NPs)       80
    • 3.12.1    Properties           80
    • 3.12.2    Application in medical nanocoatings        80
  • 3.13        Chitosan nanoparticles  80
    • 3.13.1    Properties           80
    • 3.13.2    Application in medical nanocoatings        82
      • 3.13.2.1                Wound dressings             82
  • 3.14        Hydrophobic and Hydrophilic coatings and surfaces          83
    • 3.14.1    Hydrophilic coatings       83
    • 3.14.2    Hydrophobic coatings     83
      • 3.14.2.1                Properties           84
      • 3.14.2.2                Application in facemasks              85
  • 3.15        Superhydrophobic coatings and surfaces               85
    • 3.15.1    Properties           85
      • 3.15.1.1                Anti-microbial use           86
      • 3.15.1.2                Durability issues               87
      • 3.15.1.3                Nanocellulose   87
  • 3.16        Oleophobic and omniphobic coatings and surfaces           88
    • 3.16.1    SLIPS     88
    • 3.16.2    Covalent bonding             89
    • 3.16.3    Step-growth graft polymerization             89
    • 3.16.4    Applications       89

 

4              MARKET SEGMENT ANALYSIS, MEDICAL COATINGS MARKET         91

  • 4.1          ANTI-MICROBIAL, ANTI-VIRAL AND ANTI-FUNGAL NANOCOATINGS           91
    • 4.1.1      Market drivers and trends            93
    • 4.1.2      Applications       98
    • 4.1.3      Global revenues 2010-2030          99
    • 4.1.4      Companies         103
  • 4.2          ANTI-FOULING AND EASY-TO-CLEAN NANOCOATINGS     106
    • 4.2.1      Market drivers and trends            107
    • 4.2.2      Benefits of anti-fouling and easy-to-clean nanocoatings 108
    • 4.2.3      Applications       108
    • 4.2.4      Global revenues 2010-2030          108
    • 4.2.5      Companies         112
  • 4.3          SELF-CLEANING (BIONIC) NANOCOATINGS            115
    • 4.3.1      Market drivers and trends            116
    • 4.3.2      Benefits of self-cleaning nanocoatings    116
    • 4.3.3      Global revenues 2010-2030          117
    • 4.3.4      Companies         121
  • 4.4          SELF-CLEANING (PHOTOCATALYTIC) NANOCOATINGS      123
    • 4.4.1      Market drivers and trends            124
    • 4.4.2      Benefits of photocatalytic self-cleaning nanocoatings      124
    • 4.4.3      Applications       125
      • 4.4.3.1   Self-Cleaning Coatings   125
      • 4.4.3.2   Indoor Air Pollution and Sick Building Syndrome 125
      • 4.4.3.3   Outdoor Air Pollution     125
      • 4.4.3.4   Water Treatment             126
    • 4.4.4      Global revenues 2010-2030          126
    • 4.4.5      Companies         131
  • 4.5          ANTI-FOGGING COATINGS           134
    • 4.5.1      Applications       134

 

5              COMPANY PROFILES       135 (107 company profiles)

 

6              RESEARCH METHODOLOGY         220

  • 6.1          Aims and objectives of the study               220
  • 6.2          Market definition             221
    • 6.2.1      Properties of nanomaterials        221
  • 6.2.2      Categorization   222

 

7              REFERENCES       224

 

TABLES

  • Table 1. Properties of nanocoatings.        19
  • Table 2. Market drivers and trends in nanocoatings.         20
  • Table 3: End user markets for nanocoatings.        26
  • Table 4: Global revenues for nanocoatings, 2010-2030, millions USD.        29
  • Table 5: Market and technical challenges for nanocoatings.           31
  • Table 6. Toxicity and environmental considerations for anti-viral coatings.              32
  • Table 7: Technology for synthesizing nanocoatings agents.            37
  • Table 8: Film coatings techniques.            38
  • Table 9: Nanomaterials used in nanocoatings and applications.    51
  • Table 10: Graphene properties relevant to application in coatings.             54
  • Table 11. Bactericidal characters of graphene-based materials.   56
  • Table 12. Markets and applications for nanocoatings in medical and healthcare.  57
  • Table 13. Commercial activity in antimicrobial and antiviral nanocoatings graphene nanocoatings.              58
  • Table 14. Markets and applications for antimicrobial nanosilver nanocoatings.     62
  • Table 15. Companies developing antimicrobial silver nanocoatings.           64
  • Table 16. Antibacterial effects of ZnO NPs in different bacterial species.  73
  • Table 17. Types of carbon-based nanoparticles as antimicrobial agent, their mechanisms of action and characteristics.                78
  • Table 18. Companies developing antimicrobial copper nanocoatings.        79
  • Table 19. Mechanism of chitosan antimicrobial action.    81
  • Table 20: Contact angles of hydrophilic, super hydrophilic, hydrophobic and superhydrophobic surfaces. 84
  • Table 21: Disadvantages of commonly utilized superhydrophobic coating methods.           87
  • Table 22: Applications of oleophobic & omniphobic coatings.       89
  • Table 23: Anti-microbial, anti-viral and anti-fungal nanocoatings-Nanomaterials used, principles, properties and applications        92
  • Table 24. Nanomaterials utilized in antimicrobial and antiviral nanocoatings coatings-benefits and applications.   97
  • Table 25: Antimicrobial and antiviral nanocoatings markets and applications.        99
  • Table 26: Market assessment of  antimicrobial and antiviral nanocoatings.             100
  • Table 27: Opportunity for antimicrobial and antiviral nanocoatings.           100
  • Table 28: Revenues for antimicrobial and antiviral nanocoatings, 2010-2030, US$.              101
  • Table 29: Antimicrobial and antiviral nanocoatings product and application developers.  103
  • Table 30: Anti-fouling and easy-to-clean nanocoatings-Nanomaterials used, principles, properties and applications.                106
  • Table 31: Market drivers and trends in Anti-fouling and easy-to-clean nanocoatings.         107
  • Table 32: Anti-fouling and easy-to-clean nanocoatings markets, applications and potential addressable market.   109
  • Table 33: Market assessment for anti-fouling and easy-to-clean nanocoatings.     109
  • Table 34: Revenues for anti-fouling and easy-to-clean nanocoatings, 2010-2030, US$.       110
  • Table 35: Anti-fouling and easy-to-clean nanocoatings product and application developers.           112
  • Table 36: Self-cleaning (bionic) nanocoatings-Nanomaterials used, principles, properties and applications.              115
  • Table 37: Market drivers and trends in Self-cleaning (bionic) nanocoatings.            116
  • Table 38: Self-cleaning (bionic) nanocoatings-Markets and applications.  118
  • Table 39: Market assessment for self-cleaning (bionic) nanocoatings.       118
  • Table 40: Revenues for self-cleaning nanocoatings, 2010-2030, US$.         119
  • Table 41: Self-cleaning (bionic) nanocoatings product and application developers.             121
  • Table 42: Self-cleaning (photocatalytic) nanocoatings-Nanomaterials used, principles, properties and applications.                123
  • Table 43: Market drivers and trends in photocatalytic nanocoatings.         124
  • Table 44: Photocatalytic nanocoatings-Markets, applications and potential addressable market size by 2027.          127
  • Table 45: Market assessment for self-cleaning (photocatalytic) nanocoatings.      128
  • Table 46: Revenues for self-cleaning (photocatalytic) nanocoatings, 2010-2030, US$.         128
  • Table 47: Self-cleaning (photocatalytic) nanocoatings product and application developers.             131
  • Table 48. Market overview of anti-fog coatings in healthcare and medical.             134
  • Table 49. Photocatalytic coating schematic.          156
  • Table 50: Categorization of nanomaterials.           222

 

FIGURES

  • Figure 1. Schematic of anti-viral coating using nano-actives for inactivation of any adhered virus on the surfaces. 23
  • Figure 2. Face masks coated with antibacterial & antiviral nanocoating.   25
  • Figure 3: Global revenues for nanocoatings, 2010-2030, millions USD.      30
  • Figure 4: Regional demand for nanocoatings, 2019, millions USD.               31
  • Figure 5: Hydrophobic fluoropolymer nanocoatings on electronic circuit boards. 36
  • Figure 6: Nanocoatings synthesis techniques.      38
  • Figure 7: Techniques for constructing superhydrophobic coatings on substrates. 40
  • Figure 8: Electrospray deposition.             42
  • Figure 9: CVD technique.              43
  • Figure 10: Schematic of ALD.       45
  • Figure 11. A substrate undergoing layer-by-layer (LbL) nanocoating.         46
  • Figure 12: SEM images of different layers of TiO2 nanoparticles in steel surface.  46
  • Figure 13: The coating system is applied to the surface. The solvent evaporates. 48
  • Figure 14: A first organization takes place where the silicon-containing bonding component (blue dots in figure 2) bonds covalently with the surface and cross-links with neighbouring molecules to form a strong three-dimensional.                48
  • Figure 15: During the curing, the compounds organise themselves in a nanoscale monolayer. The fluorine-containing repellent component (red dots in figure) on top makes the glass hydro- phobic and oleophobic.  48
  • Figure 16: Graphair membrane coating. 54
  • Figure 17: Antimicrobial activity of Graphene oxide (GO).              55
  • Figure 18: Hydrophobic easy-to-clean coating.    60
  • Figure 19 Anti-bacterial mechanism of silver nanoparticle coating.             61
  • Figure 20: Mechanism of photocatalysis on a surface treated with TiO2 nanoparticles.      66
  • Figure 21:  Schematic showing the self-cleaning phenomena on superhydrophilic surface.              66
  • Figure 22: Titanium dioxide-coated glass (left) and ordinary glass (right). 68
  • Figure 23:  Self-Cleaning mechanism utilizing photooxidation.      68
  • Figure 24: Schematic of photocatalytic air purifying pavement.   69
  • Figure 25: Schematic of photocatalytic indoor air purification filter.           70
  • Figure 26. Schematic of antibacterial activity of ZnO NPs.               73
  • Figure 27: Types of nanocellulose.            75
  • Figure 28. Mechanism of antimicrobial activity of carbon nanotubes.       77
  • Figure 29: Fullerene schematic. 77
  • Figure 30. TEM images of Burkholderia seminalis treated with (a, c) buffer (control) and (b, d) 2.0 mg/mL chitosan; (A: additional layer; B: membrane damage).               81
  • Figure 31: (a) Water drops on a lotus leaf.             83
  • Figure 32: A schematic of (a) water droplet on normal hydrophobic surface with contact angle greater than 90° and (b) water droplet on a superhydrophobic surface with a contact angle > 150°.              84
  • Figure 33: Contact angle on superhydrophobic coated surface.   86
  • Figure 34: Self-cleaning nanocellulose dishware. 88
  • Figure 35: SLIPS repellent coatings.          89
  • Figure 36: Omniphobic coatings.                90
  • Figure 37: Market drivers and trends in antimicrobial and antiviral nanocoatings. 93
  • Figure 38. Nano-coated self-cleaning touchscreen.           100
  • Figure 39: Revenues for antimicrobial and antiviral nanocoatings, 2010-2030, US$.             102
  • Figure 40. Revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates.           103
  • Figure 41: Anti-fouling treatment for heat-exchangers.   108
  • Figure 42: Markets for anti-fouling and easy clean nanocoatings, by %.    108
  • Figure 43: Potential addressable market for anti-fouling and easy-to-clean nanocoatings by 2030.                110
  • Figure 44: Revenues for anti-fouling and easy-to-clean nanocoatings 2010-2030, millions USD.     111
  • Figure 45. Revenues for anti-fouling and easy-to-clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates             112
  • Figure 46: Self-cleaning superhydrophobic coating schematic.      117
  • Figure 48: Potential addressable market for self-cleaning (bionic) nanocoatings by 2030.  119
  • Figure 49: Revenues for self-cleaning nanocoatings, 2010-2030, US$.        120
  • Figure 50. Revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates               121
  • Figure 51: Principle of superhydrophilicity.           125
  • Figure 52: Schematic of photocatalytic air purifying pavement.   126
  • Figure 53: Tokyo Station GranRoof. The titanium dioxide coating ensures long-lasting whiteness. 127
  • Figure 54: Markets for self-cleaning (photocatalytic) nanocoatings 2019, %.           127
  • Figure 55: Potential addressable market for self-cleaning (photocatalytic) nanocoatings by 2030.  128
  • Figure 56: Revenues for self-cleaning (photocatalytic) nanocoatings, 2010-2030, US$.       130
  • Figure 57. Revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates             131
  • Figure 58. Face shield with anti-fog coating.         134
  • Figure 59. GrapheneCA anti-bacterial and anti-viral coating.          162
  • Figure 60. Microlyte® Matrix bandage for surgical wounds.           169
  • Figure 61. Self-cleaning nanocoating applied to face masks.          171
  • Figure 62. NanoSeptic surfaces. 187
  • Figure 63. NascNanoTechnology personnel shown applying MEDICOAT to airport luggage carts.   190
  • Figure 64. Applications of Titanystar.       218

 

 

The Global Market for Nanocoatings in the Medical Industry
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