Nanotechnology and nanomaterials solutions for COVID-19

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Diagnostic testing, antiviral and antimicrobial coatings and surfaces, air-borne filtration, facemasks, PPE, drug delivery and therapeutics

Published May 25 2020, 273 pages, 41 tables, 51 figures

Nanotechnology and nanomaterials can significantly address the many clinical and public healthcare challenges that have arisen from the coronavirus pandemic. This analysis examines in detail how nanotechnology and nanomaterials can help in the fight against this pandemic disease, and ongoing mitigation strategies. Nano-based products are currently being developed and deployed for the containment, diagnosis, and treatment of Covid-19.

Nanotechnology and nanomaterials promise:

  • Improved and virus disabling air filtration.
  • Low-cost, scalable detection methods for the detection of viral particles
  • Enhanced personal protection equipment (PPE) including facemasks.
  • New antiviral vaccine and drug delivery platforms.
  • New therapeutic solutions.

 

Report contents include:

  • Market analysis of nano-based diagnostic tests for COVID-19 including nanosensors incorporating gold nanoparticles, iron oxide nanoparticles, graphene, quantum dots, carbon quantum dots and carbon nanotubes. Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include Abbott Laboratories, Cardea, Ferrotec (USA) Corporation, E25Bio, Grolltex, Inc., Luminex Corporation etc. 
  • Market analysis of antiviral and antimicrobial nanocoatings for surfaces including fabric (mask, gloves, doctor coats, curtains, bed sheet), metal (lifts, doors handle, nobs, railings, public transport), wood (furniture, floors and partition panels), concrete (hospitals, clinics and isolation wards) and plastics (switches, kitchen and home appliances). 
  • Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include Advanced Materials-JTJ s.r.o., Bio-Fence, Bio-Gate AG, Covalon Technologies Ltd., EnvisionSQ, GrapheneCA, Integricote, Nano Came Co. Ltd., NanoTouch Materials, LLC, NitroPep and many more.
  • Market analysis of air-borne virus filtration including photocatalytic Nano-TiO2 filters, nanofiber filers, nanosilver, nanocellulose, graphene and carbon nanotube filtration. Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include G6 Materials, Daicel FineChem Ltd., NANOVIA s.r.o., Toray Industries, Inc., Tortech Nano Fibers etc. 
  • Market analysis of nano-based facemask and other PPE products. Market revenues adjusted to pandemic outcomes. In-depth company profiles. Companies profiled include planarTECH LLC, RESPILON Group s. r. o., SITA, Sonovia Ltd. etc. 
  • Nanotherapies and drug delivery vehicles currently being produced and clinical trials of vaccines for COVID-19. Market revenues adjusted to pandemic outcomes. In-depth company profiles. In-depth company profiles. Companies profiled include Arcturus Therapeutics, Inc., Arbutus Biopharma, BlueWillow Biologics, Elastrin Therapeutics Inc., EnGeneIC Ltd. etc. 
  • Key scientific breakthroughs and developments that are underway right now.

 

 

Download Table of contents (PDF)

1    RESEARCH SCOPE AND METHODOLOGY..................... 20

  • 1.1    Report scope.............................................................................................20
  • 1.2    Research methodology............................................................................ 20

 

2    INTRODUCTION.........................................................22

 

3    DIAGNOSTIC TESTING...............................................24

  • 3.1    Nanotechnology and nanomaterials solutions................................. 24
    • 3.1.1      Current Diagnostic Tests for COVID-19..............................24
    • 3.1.2      Emerging Diagnostic Tests for COVID-19..........................25
    • 3.1.3      Nanosensors/nanoparticles (silver nanoclusters, Gold nanoparticles, Iron oxide nanoparticles, Quantum dot barcoding, nanowires, silica nanoparticles) ........................................................................28
    • 3.1.4      Carbon nanomaterials for diagnostic testing.....................31
  • 3.2    Market revenues..............................................................................34
    • 3.2.1      Market estimates adjusted to pandemic demand, forecast to 2025.......... 34
  • 3.3    Companies......................................................................................36 (41 COMPANY PROFILES)
  • 3.4    Academic research........................................................................ 62

 

4    ANTIVIRAL AND ANTIMICROBIAL COATINGS AND SURFACES 64

  • 4.1    Nanotechnology and nanomaterials solutions............................. 64
    • 4.1.1      Nanocoatings............................................................. 67
    • 4.1.2      Applications............................................................ 70
  • 4.1.3      Anti-viral nanoparticles and nanocoatings....................72
    • 4.1.3.1        Reusable Personal Protective Equipment (PPE)...... 73
    • 4.1.3.2        Wipe on coatings..................................................... 74
  • 4.1.4      Graphene-based coatings..................................................... 76
    • 4.1.4.1        Properties................................................................. 76
    • 4.1.4.2        Graphene oxide....................................................... 78
    • 4.1.4.3        Reduced graphene oxide (rGO)............................. 79
    • 4.1.4.4        Markets and applications.....................................80
  • 4.1.5      Silicon dioxide/silica nanoparticles (Nano-SiO2) -based coatings........... 81
    • 4.1.5.1        Properties............................................................. 81
    • 4.1.5.2        Antimicrobial and antiviral activity.....................82
    • 4.1.5.3        Easy-clean and dirt repellent...............................83
  • 4.1.6      Nanosilver-based coatings................................................. 84
    • 4.1.6.1        Properties.............................................................. 84
    • 4.1.6.2        Antimicrobial and antiviral activity..................... 84
    • 4.1.6.3        Markets and applications..................................... 85
    • 4.1.6.4        Commercial activity............................................... 86
  • 4.1.7      Titanium dioxide nanoparticle-based coatings....................87
    • 4.1.7.1        Properties............................................................... 87
    • 4.1.7.2        Exterior and construction glass coatings............... 89
    • 4.1.7.3        Outdoor air pollution...........................................91
    • 4.1.7.4        Interior coatings................................................... 91
    • 4.1.7.5        Medical facilities.................................................. 92
    • 4.1.7.6        Wastewater Treatment.........................................92
    • 4.1.7.7        Antimicrobial coating indoor light activation......... 92
  • 4.1.8      Zinc oxide nanoparticle-based coatings.............................. 93
    • 4.1.8.1        Properties................................................................ 93
    • 4.1.8.2        Antimicrobial activity............................................ 94
  • 4.1.9      Nanocellullose (cellulose nanofibers and cellulose nanocrystals)-based coatings..........96
    • 4.1.9.1        Properties............................................................... 96
    • 4.1.9.2        Antimicrobial activity............................................97
  • 4.1.10    Carbon nanotube-based coatings........................................98
    • 4.1.10.1      Properties............................................................... 98
    • 4.1.10.2      Antimicrobial activity............................................ 98
  • 4.1.11    Fullerene-based coatings..................................................... 99
    • 4.1.11.1      Properties................................................................ 99
    • 4.1.11.2      Antimicrobial activity............................................. 99
  • 4.1.12    Chitosan nanoparticle-based coatings................................ 100
    • 4.1.12.1      Properties.............................................................. 100
    • 4.1.12.2      Wound dressings................................................... 102
    • 4.1.12.3      Packaging coatings and films................................. 102
    • 4.1.12.4      Food storage............................................................ 102
  • 4.1.13    Copper nanoparticle-based coatings.................................... 103
    • 4.1.13.1      Properties................................................................ 103
    • 4.1.13.2      Application in antimicrobial nanocoatings............ 103
  • 4.2    Market revenues....................................................................... 103
    • 4.2.1      Market revenues adjusted to pandemic demand, forecast to 2030.......... 103
  • 4.3    Companies................................................................................. 108 (112 COMPANY PROFILES)
  • 4.4    Academic research.................................................................... 189

 

5    AIR-BORNE VIRUS FILTRATION......................191

  • 5.1    Nanotechnology and nanomaterials solutions (nanoparticles titanium dioxide, Polymeric nanofibers, Nanosilver, Nanocellulose, Graphene, Carbon nanotubes) ................................................191
  • 5.2    Market revenues............................................ 197
    • 5.2.1      Market estimates adjusted to pandemic demand, forecast to 2025..........197
  • 5.3    Companies...................................................... 199 (31 COMPANY PROFILES)
  • 5.4    Academic research.......................................... 222

 

6    FACEMASKS AND OTHER PPE........... 224

  • 6.1    Nanotechnology and nanomaterials solutions (Polymer nanofibers, Nanocellulose, Nanosilver, Graphene) ............................................................. 224
  • 6.2    Market revenues.............................................. 225
    • 6.2.1      Market estimates adjusted to pandemic demand, forecast to 2025........ 225
  • 6.3    Companies......................................................... 227 (10 COMPANY PROFILES)
  • 6.4    Academic research............................................233

 

7    DRUG DELIVERY AND THERAPEUTICS....................... 234

  • 7.1    Nanotechnology and nanomaterials solutions...................................... 234
    • 7.1.1      Products....................................................................................236
    • 7.1.2      Nanocarriers............................................................................. 239
    • 7.1.3      Nanovaccines...........................................................................242
  • 7.2    Market revenues...................................................................................244
    • 7.2.1      Market estimates adjusted to pandemic demand, forecast to 2025............ 244
  • 7.3    Companies............................................................................................245 (45 COMPANY PROFILES)
  • 7.4    Academic research................................................................................ 269

8    REFERENCES............................................................270

 

Tables

  • Table 1. Current Diagnostic Tests for COVID-19..................................... 24
  • Table 2. Development phases of diagnostic tests.....................................26
  • Table 3. Emerging Diagnostic Tests for COVID-19................................... 26
  • Table 4. Nanoparticles for diagnostic testing-Types of nanoparticles, properties and application......28
  • Table 5. Gold nanoparticle reagent suppliers list....................................30
  • Table 6. Carbon nanomaterials for diagnostic testing-types, properties and applications............ 33
  • Table 7. Global revenues for nanotech-based diagnostics and testing, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates................................................................. 34
  • Table 8. Academic research in nano-based COVID-19 diagnostics and testing.............62
  • Table 9: Anti-microbial and antiviral nanocoatings-Nanomaterials used, principles, properties and applications....................................................................................................... 65
  • Table 10. Nanomaterials utilized in antimicrobial and antiviral nanocoatings coatings-benefits and applications....................................................................................................... 68
  • Table 11: Properties of nanocoatings................................................................ 69
  • Table 12: Antimicrobial and antiviral nanocoatings markets and applications..... 71
  • Table 13: Nanomaterials used in nanocoatings and applications............................75
  • Table 14: Graphene properties relevant to application in coatings........................ 77
  • Table 15. Bactericidal characters of graphene-based materials.............................. 79
  • Table 16. Markets and applications for antimicrobial and antiviral nanocoatings graphene nanocoatings... 80
  • Table 17. Markets and applications for antimicrobial and antiviral nanosilver coatings.......... 85
  • Table 18. Commercial activity in antimicrobial nanosilver nanocoatings................................. 87
  • Table 19. Antibacterial effects of ZnO NPs in different bacterial species..................................95
  • Table 20. Types of carbon-based nanoparticles as antimicrobial agent, their mechanisms of action and characteristics........................................................................................................................ 100
  • Table 21. Mechanism of chitosan antimicrobial action........................................................101
  • Table 22. Global revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................................ 104
  • Table 23. Global revenues for Anti-fouling & easy clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................................ 105
  • Table 24. Global revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates................................................................................. 106
  • Table 25. Global revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 107
  • Table 26. Antimicrobial, antiviral and antifungal nanocoatings research in academia................189
  • Table 27. Cellulose nanofibers (CNF) membranes............................................... 191
  • Table 28: Comparison of CNT membranes with other membrane technologies............ 192
  • Table 29. Nanomaterials in air-borne virus filtration-properties and applications........................................ 194
  • Table 30. Global revenues for nanotech-based air-borne virus filtration, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates................................197
  • Table 31: Oji Holdings CNF products.............................................................217
  • Table 32. Academic research in nano-based air-borne virus filtration......... 222
  • Table 33. Nanomaterials in facemasks and other PPE-properties and applications...........224
  • Table 34. Global revenues for nanotech-based facemasks and PPE, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 225
  • Table 35. Academic research in nano-based facemasks and other PPE.........233
  • Table 36. Applications in drug delivery and therapeutics, by nanomaterials type-properties and applications................................................................................................... 234
  • Table 37. Nanotechnology drug products..................................................... 236
  • Table 38. List of antigens delivered by using different nanocarriers........... 241
  • Table 39. Nanoparticle-based vaccines......................................................... 243
  • Table 40. Global revenues for nano-based drug delivery and therapeutics, 2019-2030, billion US$, adjusted for COVID-19 related demand, conservative and high estimates.......................................................... 244
  • Table 41. Academic research in nano-based drug delivery and therapeutics to address COVD-19........... 269

 

Figures

  • Figure 1. Anatomy of COVID-19 Virus.....................................................22
  • Figure 2. Graphene-based sensors for health monitoring......................32
  • Figure 3. Schematic of COVID-19 FET sensor incorporating graphene...... 33
  • Figure 4. Global revenues for nanotech-based diagnostics and testing, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................35
  • Figure 5. Printed graphene biosensors................................................ 38
  • Figure 6. AGILE R100 system...............................................................41
  • Figure 7. nano-screenMAG particles....................................................43
  • Figure 8. GFET sensors......................................................................... 47
  • Figure 9. DNA endonuclease-targeted CRISPR trans reporter (DETECTR) system...........50
  • Figure 10. SGTi-flex COVID-19 IgM/IgG............................................60
  • Figure 11. Schematic of anti-viral coating using nano-actives for inactivation of any adhered virus on the surfaces................................................................................................... 73
  • Figure 12: Graphair membrane coating................................................77
  • Figure 13: Antimicrobial activity of Graphene oxide (GO)..................... 79
  • Figure 14. Nano-coated self-cleaning touchscreen.................................83
  • Figure 15: Hydrophobic easy-to-clean coating......................................83
  • Figure 16 Anti-bacterial mechanism of silver nanoparticle coating............. 85
  • Figure 17: Mechanism of photocatalysis on a surface treated with TiO2 nanoparticles..... 88
  • Figure 18:  Schematic showing the self-cleaning phenomena on superhydrophilic surface....... 88
  • Figure 19: Titanium dioxide-coated glass (left) and ordinary glass (right)................ 90
  • Figure 20:  Self-Cleaning mechanism utilizing photooxidation............................... 90
  • Figure 21: Schematic of photocatalytic air purifying pavement...............................91
  • Figure 22: Schematic of photocatalytic water purification...................................... 92
  • Figure 23. Schematic of antibacterial activity of ZnO NPs....................................... 95
  • Figure 24: Types of nanocellulose.............................................................................. 97
  • Figure 25. Mechanism of antimicrobial activity of carbon nanotubes....................... 98
  • Figure 26: Fullerene schematic....................................................................................99
  • Figure 27. TEM images of Burkholderia seminalis treated with (a, c) buffer (control) and (b, d) 2.0 mg/mL chitosan; (A: additional layer; B: membrane damage)........................................................................... 101
  • Figure 28. Global revenues for antimicrobial and antiviral nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 105
  • Figure 29. Global revenues for anti-fouling and easy-to-clean nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 106
  • Figure 30. Global revenues for self-cleaning (bionic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates................................................................................. 107
  • Figure 31. Global revenues for self-cleaning (photocatalytic) nanocoatings, 2019-2030, US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 108
  • Figure 32. Lab tests on DSP coatings......................................................... 128
  • Figure 33. GrapheneCA anti-bacterial and anti-viral coating..................... 134
  • Figure 34. Microlyte® Matrix bandage for surgical wounds........................ 141
  • Figure 35. Self-cleaning nanocoating applied to face masks......................... 143
  • Figure 36. NanoSeptic surfaces......................................................................162
  • Figure 37. NascNanoTechnology personnel shown applying MEDICOAT to airport luggage carts............ 167
  • Figure 38. Basic principle of photocatalyst TiO2.......................................... 194
  • Figure 39. Schematic of photocatalytic indoor air purification filter............. 194
  • Figure 40. Global revenues for nanotech-based air-borne virus filtration, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates.......................................................... 198
  • Figure 41. Multi-layered cross section of CNF-nw.................................201
  • Figure 42: Properties of Asahi Kasei cellulose nanofiber nonwoven fabric...........201
  • Figure 43: CNF nonwoven fabric............................................................... 203
  • Figure 44: CNF gel......................................................................................210
  • Figure 45. CNF clear sheets....................................................................... 216
  • Figure 46. Graphene anti-smog mask........................................................ 223
  • Figure 47. Global revenues for nanotech-based facemasks and PPE, 2019-2030, millions US$, adjusted for COVID-19 related demand, conservative and high estimates............................................................... 226
  • Figure 48. FNM’s nanofiber-based respiratory face mask.......................227
  • Figure 49. ReSpimask® mask.................................................................. 231
  • Figure 50. Schematic of different nanoparticles used for intranasal vaccination......................................... 240
  • Figure 51. Global revenues for nano-based drug delivery and therapeutics, 2019-2030, billion US$, adjusted for COVID-19 related demand, conservative and high estimates....................................................245

 

 

 

Nanotechnology and nanomaterials solutions for COVID-19
Nanotechnology and nanomaterials solutions for COVID-19
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Nanotechnology and nanomaterials solutions for COVID-19
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